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PI-3065 | Inhibitor of PIK3CD
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PIK3CD
  • Ki, IC50:1.5 nM; 15 nM
  • IC50:36, 38 nM
Inhibitor
up to 500 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selective against PI3K family members: p110alpha, beta and gamma (1.1, 2.3, 27.5 uM). No signific ...

Potency
Cellular
In Vitro

PIK3CD

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse
Dose: 75 mg/Kg
Route of delivery: Oral

Reference: --

Orthogonal Probes def

Pictilisib, Idelalisib

Chemical Information

Molecular Formula C27H31FN6OS
SMILEs Fc1ccc2[nH]ccc2c1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC4CC4)CC3)cc2n1
InChI InChI=1S/C27H31FN6OS/c28-21-3-4-22-20(5-6-29-22)24(21)26-30-23-15-19(17-33-9-7-32(8-10-33)16-18-1-2-18)36-25(23)27(31-26)34-11-13-35-14-12-34/h3-6,15,18,29H,1-2,7-14,16-17H2
Molecular weight 506.23 Da
AlogP 4.342900000000004
HBond acceptors 7
HBond donors 1
Atoms 67

References

Publications

Cross References

canSARChEMBLBindingDBPubMed

Vendors

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Expert Reviews

by SERP
(on 5 Jun 2021)
Cellular Use Rating
In Model Organisms
PI-3065 is an older and well-studied PI3Kdelta inhibitor. The compound lacks a negative control and overall, off-target evaluation is somewhat modest. While the selectivity within the family has been...
by SERP
(on 25 Jun 2021)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
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