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PFI-653 | PFI-653 : Inhibitor of VNN1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
VNN1
  • IC50:6.85 nM
  • IC50:9.0 nM
Inhibitor
1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family - Nitrilase family selectivity: BTD (Biotinidase): IC50 > 50 µM (>7 ...

Potency
Cellular
In Vitro

VNN1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

Other Reference: not yet published

In Vivo Validations

Rat
Dose: 2 mg/kg IV, 10 mg/kg PO
Route of delivery: Invitrous, Oral
Plasma half life: 1 h (IV)
Area Under the Curve:: 1790 ng h/mL IV, 8540 h/mL PO
Fb : 96% (PO)
Target engagement assay: PO: Dose vehicle: 10% DMSO / 30% PEG400 / 60% Water. Rat fu = 0.87

Other Reference: not yet published

Negative Control Compounds

CANSAR3511558
Notes: PFI-653-N: Human VNN1 assay: IC50 > 17.6 µM Human plasma VNN1 assay: IC50 > 3 µM

Chemical Information

Molecular Formula C18H22N6O2
SMILEs O=C(c1cnc(NCc2cnccn2)nc1)N1CCC2(CCOCC2)C1
InChI InChI=1S/C18H22N6O2/c25-16(24-6-1-18(13-24)2-7-26-8-3-18)14-9-21-17(22-10-14)23-12-15-11-19-4-5-20-15/h4-5,9-11H,1-3,6-8,12-13H2,(H,21,22,23)
Molecular weight 354.18 Da
AlogP 0.0
HBond acceptors 8
HBond donors 1
Atoms 48

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Expert Reviews

No SERP comments found for PFI-653

Probe PFI-653 is in the process of SERP review.

Please continue to check back for new reviews and commentary.