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OTSSP167 | OTSSP167: ATP competitive inhibitor of MELK
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MELK
  • IC50:0.41 nM
  • IC50:2.3 - 97 nM
ATP competitive
up to 100 nM

Selectivity

Potency
Cellular
In Vitro

MELK

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.18632/oncotarget.790

In Vivo Validations

Mouse
Dose: 1-20 mg/Kg
Route of delivery: Intravenous, Oral

Reference: --

Negative Control Compounds

Cpd1

Chemical Information

Molecular Formula C25H28Cl2N4O2
SMILEs CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1
InChI InChI=1S/C25H28Cl2N4O2/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29)/t15-,17-
Molecular weight 486.16 Da
AlogP 0.0
HBond acceptors 6
HBond donors 2
Atoms 61

References

Publications

Cross References

canSARChEMBLBindingDBBindingDBPDB

Vendors

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Expert Reviews

by SERP
(on 6 May 2016 )
Cellular Use Rating
Broad kinase selectivity data is not available for this compound.
by SERP
(on 16 May 2016 )
Cellular Use Rating
In Model Organisms
Recently reported selectivity data show that this is not a selective MELK inhibitor (http://www.kinase-screen.mrc.ac.uk/screening-compounds/594372). Based on the selectivity data, I do not recommend...
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