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OSMI-4 | OSMI-4 : Inhibitor of OGT
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OGT
  • Kd:8 nM
  • EC50:~3000 nM
Inhibitor
up to 10 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Proteomics after treatment with 20 uM of HEK293T cells shows significant changes in abundance for XB ...

Potency
Cellular
In Vitro

OGT

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jacs.8b07328

Chemical Information

Molecular Formula C27H26ClN3O7S2
SMILEs CCOC(=O)CN(Cc1cccs1)C(=O)[C@H](NS(=O)(=O)c1cc2ccc(=O)[nH]c2cc1Cl)c1ccccc1OC
InChI InChI=1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1
Molecular weight 603.09 Da
AlogP 0.0
HBond acceptors 10
HBond donors 2
Atoms 66

Vendors

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Expert Reviews

by SERP+
(on 23 Sept 2024 )
Cellular Use Rating
The proposed binding mode is well in line with the biochemical data. The compound is very potent in MST binding assay, but the potency does not translate to cellular activity with EC50 of 3 uM. A selectivity...
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