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ONO-6830634 | ONO-6830634 : Activator of KCNK2 and KCNK10
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KCNK2
    • EC50:330 nM
    KCNK10
      • EC50:190 nM
      Activator
      1-10 µM
      up to 5 uM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Compound 20 was >91-fold selective in the K2P 86Rb flux panel against TASK-1, TASK-2, TASK-3, and TW ...
      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Panel of 72 targets including GPCRs, ion channels, transporters and nuclear hormones was performed o ...

      Potency
      Cellular
      In Vitro

      KCNK2

      Mode of Action: Activator

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acschemneuro.5c00032

      KCNK10

      Mode of Action: Activator

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acschemneuro.5c00032

      Chemical Information

      Molecular Formula C15H10ClF3N4O2
      SMILEs O=C(NCc1ccc(OC(F)(F)F)cc1Cl)c1ccn2cnnc2c1
      InChI InChI=1S/C15H10ClF3N4O2/c16-12-6-11(25-15(17,18)19)2-1-10(12)7-20-14(24)9-3-4-23-8-21-22-13(23)5-9/h1-6,8H,7H2,(H,20,24)
      Molecular weight 370.04 Da
      AlogP 3.2113000000000023
      HBond acceptors 6
      HBond donors 1
      Atoms 35

      Expert Reviews

      by SERP
      (on 13 Aug 2025)
      Cellular Use Rating
      In Model Organisms
      This appears to be a highly selective human dual TREK-1/2 probe, which is very selective against the K2P ion channel family and 72 GPCRs, ion channels and transporters (Eurofins Lead Profiling panel)....
      by SERP
      (on 20 Aug 2025)
      Cellular Use Rating
      In Model Organisms
      ONO-6830634 is a useful probe to study the role TREK-1 and TREK-2 in cells. The compound is potent and selective. It may also be applicable in vivo. However, prior to its use in animal studies, in vitro...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria