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ONO-6830634 | ONO-6830634 : Activator of KCNK2 and KCNK10
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
KCNK2
    • EC50:330 nM
    KCNK10
      • EC50:190 nM
      Activator
      1-10 µM
      up to 5 uM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Compound 20 was >91-fold selective in the K2P 86Rb flux panel against TASK-1, TASK-2, TASK-3, and TW ...
      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Panel of 72 targets including GPCRs, ion channels, transporters and nuclear hormones was performed o ...

      Potency
      Cellular
      In Vitro

      KCNK2

      Mode of Action: Activator

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acschemneuro.5c00032

      KCNK10

      Mode of Action: Activator

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1021/acschemneuro.5c00032

      Chemical Information

      Molecular Formula C15H10ClF3N4O2
      SMILEs O=C(NCc1ccc(OC(F)(F)F)cc1Cl)c1ccn2cnnc2c1
      InChI InChI=1S/C15H10ClF3N4O2/c16-12-6-11(25-15(17,18)19)2-1-10(12)7-20-14(24)9-3-4-23-8-21-22-13(23)5-9/h1-6,8H,7H2,(H,20,24)
      Molecular weight 370.04 Da
      AlogP 3.2113000000000023
      HBond acceptors 6
      HBond donors 1
      Atoms 35

      Expert Reviews

      by SERP
      (on 13 Aug 2025 )
      Cellular Use Rating
      In Model Organisms
      This appears to be a highly selective human dual TREK-1/2 probe, which is very selective against the K2P ion channel family and 72 GPCRs, ion channels and transporters (Eurofins Lead Profiling panel)....
      by SERP
      (on 20 Aug 2025 )
      Cellular Use Rating
      In Model Organisms
      ONO-6830634 is a useful probe to study the role TREK-1 and TREK-2 in cells. The compound is potent and selective. It may also be applicable in vivo. However, prior to its use in animal studies, in vitro...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria