ONO-2920632 |
ONO-2920632 : Activator of KCNK10
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| KCNK10 |
|
Activator
up to 10 uM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity was assessed among the K2P family of ion channels as well as a more comprehensive evalua ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
In the Eurofins Lead Profiling panel of 72 GPCRs, ion channels and transporters, there were no displ ...
Potency Cellular
In Vitro
KCNK10
Mode of Action: Activator
Structure-Activity-Relationship data available? No
DOI Reference: 10.1021/acschemneuro.5c00032
In Vivo Validations
Rat
Dose: 3 mg/Kg
Route of delivery:
Oral
Plasma half life:
24 h
Cmax:
3660 ng/mL
Tmax:
7.0 h
Area Under the Curve::
64900 ng*h/mL
DOI Reference: 10.1021/acschemneuro.5c00032
Mouse
Dose: 3 mg/Kg
Route of delivery:
Oral
Plasma half life:
19 h
Cmax:
3720 ng/mL
Tmax:
3.8 h
Area Under the Curve::
59000 ng*h/mL
DOI Reference: 10.1021/acschemneuro.5c00032
Dog
Dose: 0.1 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
22 h
Systemic clearance:
1.29 mL/min/Kg
Area Under the Curve::
728 ng*/mL
Volume of Distribution at Steady-State:
2230 mL/Kg
DOI Reference: 10.1021/acschemneuro.5c00032
Chemical Information
| Molecular Formula | C15H10F4N4O2 |
| SMILEs | O=C(NCc1ccc(OC(F)(F)F)cc1F)c1ccc2ncnn2c1 |
| InChI | InChI=1S/C15H10F4N4O2/c16-12-5-11(25-15(17,18)19)3-1-9(12)6-20-14(24)10-2-4-13-21-8-22-23(13)7-10/h1-5,7-8H,6H2,(H,20,24) |
| Molecular weight | 354.07 Da |
| AlogP | 2.697000000000001 |
| HBond acceptors | 6 |
| HBond donors | 1 |
| Atoms | 35 |