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Onalespib | Inhibitor of HSP90AA1, HSP90AB1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HSP90AA1
  • Kd:0.71 nM
  • IC50:30 nM
HSP90AB1
  • Kd:0.71 nM
  • IC50:30 nM
Inhibitor
10 - 100 nM
30 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
hERG inhibition 7% @ 3 uM, 42 % @ 30 uM, Clean profile against the major cytochrome P450 isoforms (≤ ...

Potency
Cellular
In Vitro

HSP90AA1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/jm100060b

HSP90AB1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/jm100060b

In Vivo Validations

Mouse
Dose: 2-60 mg/Kg
Route of delivery: Intravenous
Plasma half life: 0.9-3.2 h
Systemic clearance: 113-200 mL/min/Kg

DOI Reference: 10.1021/jm100060b

Orthogonal Probes def

BIIB021
Luminespib

Chemical Information

Molecular Formula C24H31N3O3
SMILEs CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
InChI InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
Molecular weight 409.24 Da
AlogP 3.1246000000000023
HBond acceptors 6
HBond donors 2
Atoms 61

References

Publications

Cross References

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Expert Reviews

by SERP
(on 3 Jan 2022 )
Cellular Use Rating
In Model Organisms
Onalespib appears to be a selective HSP90 inhibitor with good pharmacological properties that permit in vivo dosing.
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria