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OICR-8268 | OICR-8268 : Inhibitor of DCAF1
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
DCAF1
  • Kd:38 nM
  • Kd:216 ± 76 nM
  • EC50:10500 nM
Inhibitor
10-40 µM as no maximal effect seen with 10 µM in CETSA
up to 20 uM

Selectivity

Potency
Cellular
In Vitro

DCAF1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.2c02132

Chemical Information

Molecular Formula C19H14Cl2F2N4O2
SMILEs NC(=O)C[C@H](NC(=O)c1c[nH]nc1-c1ccc(Cl)cc1F)c1ccc(F)c(Cl)c1
InChI InChI=1S/C19H14Cl2F2N4O2/c20-10-2-3-11(15(23)6-10)18-12(8-25-27-18)19(29)26-16(7-17(24)28)9-1-4-14(22)13(21)5-9/h1-6,8,16H,7H2,(H2,24,28)(H,25,27)(H,26,29)/t16-/m0/s1
Molecular weight 438.05 Da
AlogP 0.0
HBond acceptors 6
HBond donors 4
Atoms 43

Vendors

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Expert Reviews

by SERP
(on 20 Mar 2024 )
Cellular Use Rating
OICR-8268 is a highly potent DCAF1 ligand and a very useful tool compound to interrogate this E3 ligase substrate adaptor. The binding mode of the compound is backed up by a co-crystal structure and extensive...
by SERP
(on 22 Mar 2024 )
Cellular Use Rating
( The reviewer did not leave any comments )
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