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Ogerin | Positive allosteric Modulator of GPR68
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GPR68
    • pKbB:4.92
    Positive allosteric
    up to 1 uM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Screened for radioligand binding modulation of CNS GPCRs and toxic pharmacological off-targets. M ...

    Potency
    Cellular
    In Vitro

    GPR68

    Mode of Action: Positive allosteric

    Structure-Activity-Relationship data available? No

    In Vivo Validations

    Mouse
    Dose: 10 mg/Kg
    Route of delivery: Intraperitoneal
    Organ of interest (O): Brain

    Reference: --

    Negative Control Compounds

    ZINC32547799

    Chemical Information

    Molecular Formula C17H17N5O
    SMILEs Nc1nc(NCc2ccccc2)nc(-c2ccccc2CO)n1
    InChI InChI=1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
    Molecular weight 307.14 Da
    AlogP 2.2252000000000005
    HBond acceptors 6
    HBond donors 4
    Atoms 40

    References

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      Expert Reviews

      by SERP
      (on 18 Oct 2020 )
      Cellular Use Rating
      In Model Organisms
      Ogerin has moderate affinity at two GPCRs, 5-HT2B and the A2A receptor.
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria