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NX-1607 | NX-1607 : Inhibitor of CBLB
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CBLB
  • Kd:12 ± 6 nM
  • ΔTm:12 ± 0.2 °C
  • Ki:1.84 nM
  • ΔTm:>15 °C
  • EC50:54.3 nM
  • EC50:26.8 nM
Inhibitor
1 uM, up to 10 uM

Selectivity

Potency
Cellular
In Vitro

CBLB

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s42003-023-05655-8

In Vivo Validations

Mouse
Dose: 1 mg/Kg
Route of delivery: Intravenous
Plasma half life: 0.31 h
Systemic clearance: 59.70 mL/min/Kg
Area Under the Curve:: 281 h*ng/mL
Volume of Distribution at Steady-State: 1.55 L/Kg

DOI Reference: 10.1016/j.ejmech.2025.117488

Dose: 10 mg/Kg
Route of delivery: Oral
Plasma half life: 2.68 h
Cmax: 629 ng/mL
Tmax: 0.33 h
Area Under the Curve:: 690 h*ng/mL
Bioavailability: 24.6%

DOI Reference: 10.1038/s42003-023-05655-8

Chemical Information

Molecular Formula C30H34F3N5O
SMILEs C[C@H]1CCCN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc([C@]4(c5nncn5C)C[C@@H](C)C4)c2)C3=O)C1
InChI InChI=1S/C30H34F3N5O/c1-19-6-5-9-37(15-19)16-21-10-24-25(26(11-21)30(31,32)33)17-38(27(24)39)23-8-4-7-22(12-23)29(13-20(2)14-29)28-35-34-18-36(28)3/h4,7-8,10-12,18-20H,5-6,9,13-17H2,1-3H3/t19-,20-,29+/m0/s1
Molecular weight 537.27 Da
AlogP 5.942200000000007
HBond acceptors 6
HBond donors --
Atoms 73

Expert Reviews

by SERP
(on 27 Nov 2025 )
Cellular Use Rating
The primary reference demonstrates that C7683 is a potent, high-affinity (KD ~8–12 nM) small-molecule inhibitor of the E3 ubiquitin ligase Cbl-b, capable of stabilizing the protein both in vitro and in...
by SERP
(on 3 Dec 2025 )
Cellular Use Rating
The compound shows a very high potency when binding to Cbl-b in vitro. Cellular target engagement in HEK293 is convincingly demonstrated. The compounds appears not be toxic, and shows target-dependent...
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