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NVS-CECR2-1 | NVS-CECR2-1 : Inhibitor of CECR2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CECR2
  • Kd:80 nM
  • IC50:47 nM
  • ΔTm:12.52 °C
  • IC50:255 nM
  • Activity:100 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
NVS-CECR2-1 shows no cross reactivity among bromodomains and no significant inhibition of protein ki ...

Potency
Cellular
In Vitro

CECR2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41598-020-73500-7

Negative Control Compounds

NVS-CECR2-C
SMILES: CC1(C)CC(N2C=CC3=C2C=CC(C4=NC(S(=O)(CCC)=O)=CC(NC5CC5)=N4)=C3)CC(C)(C)N1

Chemical Information

Molecular Formula C27H37N5O2S
SMILEs CCCS(=O)(=O)c1nc(-c2ccc3c(ccn3C3CC(C)(C)NC(C)(C)C3)c2)c/c(=N\C2CC2)[nH]1
InChI InChI=1S/C27H37N5O2S/c1-6-13-35(33,34)25-29-22(15-24(30-25)28-20-8-9-20)18-7-10-23-19(14-18)11-12-32(23)21-16-26(2,3)31-27(4,5)17-21/h7,10-12,14-15,20-21,31H,6,8-9,13,16-17H2,1-5H3,(H,28,29,30)
Molecular weight 495.27 Da
AlogP 0.0
HBond acceptors 7
HBond donors 2
Atoms 72

Expert Reviews

No SERP comments found for NVS-CECR2-1

Probe NVS-CECR2-1 is in the process of SERP review.

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