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NUDT5-IN-9 | NUDT5-IN-9 : Antagonist of NUDT5, NUDT14
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NUDT5
  • Kd:237 nM
  • IC50:270 nM
  • EC50:1080 ± 70 nM
NUDT14
  • Kd:368 nM
  • IC50:162 nM
  • ΔTm:5.5 ± 0.3 K
Antagonist
up to 5 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity of compound 9 as a NUDT5/NUDT14 inhibitor was confirmed by extended biophysical SPR scre ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Lower potency in binding to BTK in cells (EC50 = 0.377 ± 0.062 μM) with an approximately 75-fold dec ...

Potency
Cellular
In Vitro

NUDT5

Mode of Action: Antagonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.4c00072

NUDT14

Mode of Action: Antagonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.4c00072

Orthogonal Probes def

TH5427
canSAR3935412

Chemical Information

Molecular Formula C23H24N6O
SMILEs CN1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1
InChI InChI=1S/C23H24N6O/c1-28-13-11-17(12-14-28)29-23-20(22(24)25-15-26-23)21(27-29)16-7-9-19(10-8-16)30-18-5-3-2-4-6-18/h2-10,15,17H,11-14H2,1H3,(H2,24,25,26)
Molecular weight 400.20 Da
AlogP 4.134500000000002
HBond acceptors 7
HBond donors 2
Atoms 54

Expert Reviews

No SERP comments found for NUDT5-IN-9

Probe NUDT5-IN-9 is in the process of SERP review.

Please continue to check back for new reviews and commentary.