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NK7-902 | NK7-902 : Molecular Glue of NEK7
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NEK7
  • Kd:1160 nM
  • Kd:49 nM
  • Dmax:100%
  • DC50:0.2 nM
  • Dmax:>95%
  • DC50:4.1 nM
  • Activity:1 µM
Molecular Glue
1 µM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity of NK7-902 was assessed by mass spectrometry-based proteomics analysis of human primary ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Expression proteomics analysis of NK7-902 was also done in human iPS cells which express Sal-like pr ...

Potency
Cellular
In Vitro

NEK7

Mode of Action: Molecular Glue

Structure-Activity-Relationship data available? No

DOI Reference: 10.1016/j.chembiol.2025.06.005

In Vivo Validations

Mouse
Dose: 1 mg/Kg
Route of delivery: Intravenous
Plasma half life: 2.18 h
Systemic clearance: 27.2 mL/min/Kg
Volume of Distribution at Steady-State: 2.33 L/Kg

DOI Reference: 10.1016/j.chembiol.2025.06.005

Dose: 10 mg/Kg
Route of delivery: Oral
Cmax: 1100 nM
Tmax: 1 h
Area Under the Curve:: 5690 nM*h
Bioavailability: 39%

DOI Reference: 10.1016/j.chembiol.2025.06.005

Monkey (Cynomolgus)
Dose: 1 mg/Kg
Route of delivery: Intravenous
Plasma half life: 3.47 ± 1.30 h
Systemic clearance: 26.1 ± 6.5 mL/min/Kg
Area Under the Curve:: 1570 ±373 nM*h
Volume of Distribution at Steady-State: 5.64 ± 0.326 L/Kg

DOI Reference: 10.1016/j.chembiol.2025.06.005

Dose: 0.2 mg/Kg
Route of delivery: Oral
Cmax: 9.89 ± 3.84 nM
Tmax: 2.0 ± 0 h
Area Under the Curve:: 48.0 ± 29.0 nM*h
Bioavailability: 14.3 ± 6.69%

DOI Reference: 10.1016/j.chembiol.2025.06.005

Dose: 2 mg/Kg
Route of delivery: Oral
Cmax: 257 ± 72.0 nM
Tmax: 1.0 ± 0 h
Area Under the Curve:: 1560 ± 280 nM*h
Bioavailability: 49.7 ± 8.93%

DOI Reference: 10.1016/j.chembiol.2025.06.005

Chemical Information

Molecular Formula C22H26N4O4
SMILEs CCN[C@@H]1CC[C@H]2CC[C@@H]1N2c1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
InChI InChI=1S/C22H26N4O4/c1-2-23-16-7-4-12-5-8-17(16)25(12)13-3-6-14-15(11-13)22(30)26(21(14)29)18-9-10-19(27)24-20(18)28/h3,6,11-12,16-18,23H,2,4-5,7-10H2,1H3,(H,24,27,28)/t12-,16+,17-,18?/m0/s1
Molecular weight 410.20 Da
AlogP 1.1971
HBond acceptors 8
HBond donors 2
Atoms 56

Expert Reviews

by SERP
(on 1 Sept 2025 )
Cellular Use Rating
In Model Organisms
NK7-902 is a valuable chemical probe (degrader) to study NEK7-mediated NLRP3 biology. In contrast to other tool compounds NK7-902 not only degrades human and NHP but also mouse protein. In addition, its...
by SERP
(on 8 Dec 2025 )
Cellular Use Rating
In Model Organisms
NK7-902 is a highly potent, selective CRBN-recruiting molecular glue degrader of NIMA-related kinase 7 (NEK7) with sub‑nanomolar DC50 in human primary monocytes: DC50 ≈ 0.2 nM with Dmax > 95% NEK7 degradation...
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria