Chemical Probes logo
MSD-CYP11B2 | Inhibitor of CYP11B2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CYP11B2
    • IC50:2.3 nM
    Inhibitor
    25 - 100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Human CYP11B1: IC50 = 142 nM (Assay using V79 cell lines); 61x more selective for CYP11B2 compared t ...

    Potency
    Cellular
    In Vitro

    CYP11B2

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/acsmedchemlett.5b00054

    In Vivo Validations

    Rat
    Dose: 1 mg/kg
    Route of delivery: Intravenous
    Systemic clearance: 10 mL/min/kg
    Area Under the Curve:: 4.32 μM·h·kg/mg
    Fb : 87 %
    Bioavailability: 76 %

    DOI Reference: 10.1021/acsmedchemlett.5b00054

    Monkey (Rheus)
    Dose: 0.5 mg/Kg
    Route of delivery: Intravenous
    Systemic clearance: 5 mL/min/kg
    Area Under the Curve:: 1.53 μM·h·kg/mg
    Fb : 85 %
    Bioavailability: 15 %

    DOI Reference: 10.1021/acsmedchemlett.5b00054

    Negative Control Compounds

    MSD-CYP11B2-Negative-control

    Chemical Information

    Molecular Formula C18H18FN3O
    SMILEs CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1
    InChI InChI=1S/C18H18FN3O/c1-18(2,23)12-7-11(9-20-10-12)17-21-15-6-3-13(19)8-16(15)22(17)14-4-5-14/h3,6-10,14,23H,4-5H2,1-2H3
    Molecular weight 311.14 Da
    AlogP 3.7997000000000023
    HBond acceptors 4
    HBond donors 1
    Atoms 41

    Vendors

    Note: This is not an exhaustive list and does not indicate endorsement by the portal.

    Expert Reviews

    No SERP comments found for MSD-CYP11B2

    Probe MSD-CYP11B2 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.