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MSC-4381 | Inhibitor of SLC16A3
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SLC16A3
  • IC 50:77 nM
  • IC 50:1 nM
Inhibitor
Up to 10 µM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
MSC-4381 is selective within the target family: SLC16A1 (MCT1): SNU-398 (MCT1+/4-) cells (IC50 > 4 µ ...

Potency
Cellular
In Vitro

SLC16A3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.1c00448.

Chemical Information

Molecular Formula C26H20ClN3O6S
SMILEs CCOc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C#Cc2cnc(C(=O)O)cc2OC)c2ncccc12
InChI InChI=1S/C26H20ClN3O6S/c1-3-36-22-10-11-24(25-19(22)5-4-12-28-25)37(33,34)30-20-9-8-18(27)13-16(20)6-7-17-15-29-21(26(31)32)14-23(17)35-2/h4-5,8-15,30H,3H2,1-2H3,(H,31,32)
Molecular weight 537.08 Da
AlogP 0.0
HBond acceptors 9
HBond donors 2
Atoms 57

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Expert Reviews

No SERP comments found for MSC-4381

Probe MSC-4381 is in the process of SERP review.

Please continue to check back for new reviews and commentary.