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MS4078 | MS4078 : Degrader (PROTAC) of ALK
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ALK
  • Kd:19 nM
  • DC50:11 nM
  • Dmax:90%
  • DC50:59 nM
  • Dmax:90%
  • Activity:60 nM
Degrader (PROTAC)
100 nM

Selectivity

Potency
Cellular
In Vitro

ALK

Mode of Action: Degrader (PROTAC)

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.ejmech.2018.03.071

In Vivo Validations

Mouse
Dose: 50 mg/Kg
Route of delivery: Intraperitoneal
Cmax: 3000 nM

DOI Reference: 10.1016/j.ejmech.2018.03.071

Orthogonal Probes def

TL13-112
ALECTINIB

Chemical Information

Molecular Formula C45H52ClN9O8S
SMILEs Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(CC(=O)NCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1
InChI InChI=1S/C45H52ClN9O8S/c1-25(2)63-36-22-30(27(5)21-34(36)51-45-49-23-31(46)41(53-45)50-32-10-6-7-12-37(32)64(61,62)26(3)4)28-15-19-54(20-16-28)24-39(57)48-18-17-47-33-11-8-9-29-40(33)44(60)55(43(29)59)35-13-14-38(56)52-42(35)58/h6-12,21-23,25-26,28,35,47H,13-20,24H2,1-5H3,(H,48,57)(H,52,56,58)(H2,49,50,51,53)
Molecular weight 913.33 Da
AlogP 5.70382
HBond acceptors 17
HBond donors 5
Atoms 116

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Expert Reviews

by SERP+
(on 6 Feb 2026 )
Cellular Use Rating
In Model Organisms
Although the PROTAC shows ALK degradation, it lacks selectivity assessment, so insufficient data is provided to conclude this is a selective probe for ALK. Proteosome dependent degradation has been confirmed...
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