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MRS 1754 | MRS 1754 : Antagonist of ADORA2B
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ADORA2B
    • Activity:0%
    • Ki:2 nM
    Antagonist
    100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Within target family: selective against A1, A2A and A3 Ki 403, 503, and 570 nM, respectively.

    Potency
    Cellular
    In Vitro

    ADORA2B

    Mode of Action: Antagonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1021/jm990421v

    Negative Control Compounds

    CANSAR690755
    Notes: cpd 7 A2B Ki 1760 nM

    Chemical Information

    Molecular Formula C26H26N6O4
    SMILEs CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCC)c1=O
    InChI InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)
    Molecular weight 486.20 Da
    AlogP 3.26248
    HBond acceptors 10
    HBond donors 2
    Atoms 62

    References

    Publications

    Cross References

    canSARChEMBLBindingDB

    Vendors

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    Expert Reviews

    No SERP comments found for MRS 1754

    Probe MRS 1754 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.