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MLT-748 | MLT-748 : Allosteric inhibitor of MALT1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MALT1
  • IC50:5 nM
  • Kd:42 nM
  • Kd:13 nM
  • EC50:69 nM
Allosteric
up to 2 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
MLT-748 does not show inhibitory activity on any of 22 other tested human proteases with IC50 val ...

Potency
Cellular
In Vitro

MALT1

Mode of Action: Allosteric

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41589-018-0222-1

Chemical Information

Molecular Formula C19H19Cl2N9O3
SMILEs CO[C@H](C)[C@H](OC)c1c(NC(=O)Nc2cnc(-n3nccn3)c(Cl)c2)cnc2cc(Cl)nn12
InChI InChI=1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1
Molecular weight 491.10 Da
AlogP 3.3782000000000014
HBond acceptors 12
HBond donors 2
Atoms 52

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Expert Reviews

by SERP
(on 4 Aug 2021 )
Cellular Use Rating
( The reviewer did not leave any comments )
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