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ML154 | ML154 : Antagonist of NPSR1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NPSR1
    • IC50:22.1 nM
    • IC50:36.5 nM
    • IC50:9.3 nM
    • IC50: 5.0 nM
    Antagonist
    up to 1 uM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    NCGC84 concentrations up to 10 μm did not affect intracellular Ca2+-level in cells expressing vasopr ...

    Potency
    Cellular
    In Vitro

    NPSR1

    Mode of Action: Antagonist

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1523/JNEUROSCI.4742-12.2013

    Chemical Information

    Molecular Formula C29H26BrN2PS
    SMILEs Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1.[Br-]
    InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+;
    Molecular weight 544.07 Da
    AlogP 0.0
    HBond acceptors 2
    HBond donors --
    Atoms 60

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    Expert Reviews

    by SERP
    (on 1 Feb 2023 )
    Cellular Use Rating
    ML154 has demonstrated strong on-target cellular potency and encouraging selectivity for NPSR1 over vasopressin and purinergic receptors, but was apparently not evaluated for a broader cohort of off targets....
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria