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MKI-3 | MKI-3 : Inhibitor of MASTL
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MASTL
  • IC50:5.72 ± 0.18 nM
  • Kd:1.89 nM
  • IC50:114.9 ± 10.5 nM
  • IC50:42 - 160.9 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
MKI-3 selectively inhibited MASTL over other AGC kinases, including large tumor suppressor kinase 1 ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
To further assess the kinase selectivity of MKI-3, we screened 82 kinases, including those with high ...
Selectivity Assessment Description:
Among the kinases tested, only five out of 82 exhibited over 80% inhibition, indicating a favorable ...

Potency
Cellular
In Vitro

MASTL

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.5c03599

Chemical Information

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Expert Reviews

No SERP comments found for MKI-3

Probe MKI-3 is in the process of SERP review.

Please continue to check back for new reviews and commentary.