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ME43 | ME43 : Agonist of NR4A2, NR4A1 and NR4A3
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NR4A2
  • Kd:120 nM
  • EC50:60 nM
NR4A1
    • EC50:40 nM
    NR4A3
      • EC50:70 nM
      Agonist
      up to 1 uM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Profiled on nuclear receptors outside the NR4A family, ME43 revealed moderate PXR activation as only ...

      Potency
      Cellular
      In Vitro

      NR4A2

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/acs.jmedchem.4c03104

      NR4A1

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/acs.jmedchem.4c03104

      NR4A3

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? Yes

      DOI Reference: 10.1021/acs.jmedchem.4c03104

      Negative Control Compounds

      ME113
      Notes: cpd 48 was inactive in gene reported assay EC50 10 uM
      SMILES: ClC1=C(C(N(C)C2=CC(C=CC=C3)=C3N=C2)=O)C=C(NC=C4)C4=C1

      Chemical Information

      Coming Soon...

      Expert Reviews

      by SERP
      (on 22 Feb 2026 )
      Cellular Use Rating
      Cellular activity was observed across several Nurr1 complexes with EC50s < 100 nM. Established off-target effects (eg PXR) were observed at 3 uM, suggesting that use of the probe at concentrations < or...
      by SERP
      (on 30 Mar 2026 )
      Cellular Use Rating
      ME43 is a very interesting molecule that fulfills the requirements for a chemical probe. It has been shown to demonstrate neuroprotective effects. There are several additional molecules in the public...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria