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MCC950 | MCC950 : Inhibitor of NLRP3
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NLRP3
  • KD:224 nM
  • IC50:7.5 nM BMDM; 8.1 nM HMDM
Inhibitor
10-50 mg dose in model organism studies
50 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
MCC950 does not inhibit NLRC4, AIM2, NLRP3 priming or Toll-like receptor signaling
In Cell Selectivity Assessment
Selectivity Assessment Description:
MCC950 does not inhibit NLRC4, AIM2, NLRP3 priming or Toll-like receptor signaling

Potency
Cellular
In Vitro

NLRP3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Mouse
Dose: 3 mg/Kg (IV), 20 mg/Kg (PO)
Route of delivery: Intravenous, Oral
Plasma half life: 3.27 h

Reference: --

Chemical Information

Molecular Formula C20H24N2O5S
SMILEs CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c1
InChI InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)
Molecular weight 404.14 Da
AlogP 2.9948000000000023
HBond acceptors 7
HBond donors 3
Atoms 52

References

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    Expert Reviews

    by SERP
    (on 15 Sept 2020 )
    Cellular Use Rating
    In Model Organisms
    This probe has been tested in human primary cell-based assays (BioMAP Diversity PLUS panel from Eurofins Discovery) at 370 – 10 uM. Selectively active in only one of the 12 assay systems at 370 nM,...
    by SERP
    (on 6 Jul 2022 )
    Cellular Use Rating
    In Model Organisms
    ( The reviewer did not leave any comments )
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria