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LY2090314 | LY2090314 : Inhibitor of GSK3A, GSK3B
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GSK3A
  • IC50:1.5 nM
    GSK3B
    • IC50:1.1 ± 0.3
    • IC50:0.7 ± 0.26 nM
    Inhibitor
    up to 100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Screened against a panel of diverse Kinases: Kinase IC50 GSK-3β 0.0011 Cdk4 1.8 Cdk2 2.8 PKCβII 0.42 ...

    Potency
    Cellular
    In Vitro

    GSK3A

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm049768a

    GSK3B

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm049768a

    In Vivo Validations

    Rat
    Dose: 5 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 0.358 h
    Systemic clearance: 3450 mL/h/Kg
    Cmax: 1680 ng/mL
    Tmax: 0.5 h
    Area Under the Curve:: 1260 ng*h/mL
    Volume of Distribution at Steady-State: 1189 mL/Kg

    DOI Reference: 10.1124/dmd.112.048488

    Dog
    Dose: 5 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 0.662 ± 0.145 h
    Systemic clearance: 1673 ± 540 mL/h/Kg
    Cmax: 5090 ± 2709 ng/mL
    Tmax: 0.5 ± 0.0 h
    Area Under the Curve:: 3227 ± 1060 ng*h/mL
    Volume of Distribution at Steady-State: 915 ± 415 mL/Kg

    DOI Reference: 10.1124/dmd.112.048488

    Chemical Information

    Molecular Formula C28H25FN6O3
    SMILEs O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2
    InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
    Molecular weight 512.20 Da
    AlogP 3.4168
    HBond acceptors 9
    HBond donors 1
    Atoms 63

    References

    Publications

    Cross References

    canSARChEMBLBindingDB

    Vendors

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    Expert Reviews

    by SERP
    (on 26 Feb 2023 )
    Cellular Use Rating
    In Model Organisms
    Limited (not whole kinome) selectivity data and no direct cellular target engagement assay data are provided in the primary publication, which uses downstream phospho-tau as a readout. Therefore additional...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria