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LY2090314 | LY2090314 : Inhibitor of GSK3A, GSK3B
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
GSK3A
  • IC50:1.5 nM
    GSK3B
    • IC50:1.1 ± 0.3
    • IC50:0.7 ± 0.26 nM
    Inhibitor
    up to 100 nM

    Selectivity

    In Vitro Selectivity Assessment
    Potency Assay Off-Target:
    Screened against a panel of diverse Kinases: Kinase IC50 GSK-3β 0.0011 Cdk4 1.8 Cdk2 2.8 PKCβII 0.42 ...

    Potency
    Cellular
    In Vitro

    GSK3A

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm049768a

    GSK3B

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/jm049768a

    In Vivo Validations

    Rat
    Dose: 5 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 0.358 h
    Systemic clearance: 3450 mL/h/Kg
    Cmax: 1680 ng/mL
    Tmax: 0.5 h
    Area Under the Curve:: 1260 ng*h/mL
    Volume of Distribution at Steady-State: 1189 mL/Kg

    DOI Reference: 10.1124/dmd.112.048488

    Dog
    Dose: 5 mg/Kg
    Route of delivery: Intravenous
    Plasma half life: 0.662 ± 0.145 h
    Systemic clearance: 1673 ± 540 mL/h/Kg
    Cmax: 5090 ± 2709 ng/mL
    Tmax: 0.5 ± 0.0 h
    Area Under the Curve:: 3227 ± 1060 ng*h/mL
    Volume of Distribution at Steady-State: 915 ± 415 mL/Kg

    DOI Reference: 10.1124/dmd.112.048488

    Chemical Information

    Molecular Formula C28H25FN6O3
    SMILEs O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2
    InChI InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
    Molecular weight 512.20 Da
    AlogP 3.4168
    HBond acceptors 9
    HBond donors 1
    Atoms 63

    References

    Publications

    Cross References

    canSARChEMBLBindingDB

    Vendors

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    Expert Reviews

    by SERP
    (on 26 Feb 2023)
    Cellular Use Rating
    In Model Organisms
    Limited (not whole kinome) selectivity data and no direct cellular target engagement assay data are provided in the primary publication, which uses downstream phospho-tau as a readout. Therefore additional...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria