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LNS8801 | LNS8801 : Agonist of GPER1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
GPER1
    • EC50:2 nM
    • Ki:11 nM
    • Activity:10 nM
    Agonist
    100 nM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    G-1 had no substantial binding to either ER-α or ER-β at concentrations up to 1 μM

    Potency
    Cellular
    In Vitro

    GPER1

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1038/nchembio775

    Chemical Information

    Molecular Formula C21H18BrNO3
    SMILEs CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@H](c1cc3c(cc1Br)OCO3)N2
    InChI InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1
    Molecular weight 411.05 Da
    AlogP 5.206900000000003
    HBond acceptors 4
    HBond donors 1
    Atoms 44
    PAINS * Yes

    * This is an automated alert only, and may not necessarily indicate an issue with this probe. ( Learn more about PAINS )

    References

    Publications

    Cross References

    Vendors

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    Expert Reviews

    No SERP comments found for LNS8801

    Probe LNS8801 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.