LNP-023 |
Inhibitor of CFB
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CFB |
|
|
Inhibitor
up to 1 uM
Selectivity
In Vitro Selectivity Assessment
Selectivity Assessment Description:
IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D ...
In Cell Selectivity Assessment
Selectivity Assessment Description:
LNP023 provided IC50 values of >30 μM across an internal panel of ∼110 enzymes, receptors, and ...
Potency Cellular
In Vitro
CFB
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1073/pnas.1820892116
In Vivo Validations
Mouse, Rat, Dog
Dose: 1 to 30 mg/Kg (R), 0.1 to 10 mg/Kg (D), 1 (IV), 10 (PO) mg/Kg (m)
Route of delivery:
Intravenous, Oral
Plasma half life:
7 (R) , 5.6 (D) 7.2 (m) h
Systemic clearance:
8 (R), 2 (D), 16 (m) mL/min/Kg
DOI Reference: 10.1073/pnas.1820892116
Chemical Information
| Molecular Formula | C25H30N2O4 |
| SMILEs | CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 |
| InChI | InChI=1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1 |
| Molecular weight | 422.22 Da |
| AlogP | 4.925320000000004 |
| HBond acceptors | 6 |
| HBond donors | 2 |
| Atoms | 61 |
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