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LK01003 | LK01003 : Inhibitor of RIPK3
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
RIPK3
  • IC50:2 nM
  • EC50:850 nM
  • EC50:3.7 µM
  • INH:3 µM
Inhibitor
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
The selectivity profile of LK01003 was assessed against a panel of 379 kinases. LK01003 exhibits an ...

Potency
Cellular
In Vitro

RIPK3

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41467-025-59432-8

Chemical Information

Molecular Formula C24H25N3O2S2
SMILEs CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4sc(C5CCCC5)nc4c3)c2c1
InChI InChI=1S/C24H25N3O2S2/c1-15(2)31(28,29)18-8-9-20-19(14-18)21(11-12-25-20)26-17-7-10-23-22(13-17)27-24(30-23)16-5-3-4-6-16/h7-16H,3-6H2,1-2H3,(H,25,26)
Molecular weight 451.14 Da
AlogP 6.427800000000005
HBond acceptors 5
HBond donors 1
Atoms 56

Expert Reviews

by SERP
(on 23 Jun 2025 )
Cellular Use Rating
LK01003 provides a novel tool to study RIPK3 biology. LK01003 is potent in biochemical settings and X-ray crystallographic studies corroborate its mechanism of binding and action. As a key feature, LK01003...
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