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LC-20W | LC-20W : Inhibitor of CES2
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CES2
  • IC50:1.6 nM
  • Ki:1.4 nM
  • IC50:52 nM
Inhibitor
up to 500 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
In enzymatic assay, LC-20W was 4538-fold more potent against hCES2A compared to hCES1A,

Potency
Cellular
In Vitro

CES2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.ejmech.2023.115708

Chemical Information

Molecular Formula C23H26O4
SMILEs CCCCCCC(=O)c1c(C)ccc2oc(-c3cc(OC)ccc3O)cc12
InChI InChI=1S/C23H26O4/c1-4-5-6-7-8-20(25)23-15(2)9-12-21-18(23)14-22(27-21)17-13-16(26-3)10-11-19(17)24/h9-14,24H,4-8H2,1-3H3
Molecular weight 366.18 Da
AlogP 6.275520000000006
HBond acceptors 4
HBond donors 1
Atoms 53

Expert Reviews

by SERP
(on 22 Aug 2025 )
Cellular Use Rating
While the compound is 4,538 times more potent against hCES2A than hCES1A and SAR exists, broader selectivity profiling is needed. Providing this data could support its suitability as a probe.
by SERP
(on 22 Aug 2025 )
Cellular Use Rating
( The reviewer did not leave any comments )
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