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LC-04-45 | LC-04-45 : Molecular Glue of NEK7
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NEK7
    • DC50:7 nM
    • IC50:33 nM
    • DC50:2.9 nM
    • IC50:33.03 nM
    • IC50:32.99
    Molecular Glue
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Proteome-wide selectivity was evaluated in MOLT-4 cells treated with 1 μM of LC-04-045 or DMSO for 6 ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Selectivity against NEK1, NEK2, NEK4, NEK7, NEK10 and NEK11 was assessed via immunoblot in MOLLT4 ce ...

    Potency
    Cellular
    In Vitro

    NEK7

    Mode of Action: Molecular Glue

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1002/anie.202500169

    Negative Control Compounds

    LC-04-045-Neg
    Notes: LC-04-045-Neg was not able to promote the ternary complex formation in HEK293T cells.
    SMILES: O=C([C@@H](N(CC1=C2C=CC(C3=CN=C4CN(CC5=CC=CC=C5C6=CC=CC=C6Cl)CCN43)=C1)C2=O)CC7)N(C)C7=O

    Chemical Information

    Coming Soon...

    References

    Publications

    Cross References

    Expert Reviews

    by SERP
    (on 21 Jan 2026 )
    Cellular Use Rating
    ( The reviewer did not leave any comments )
    by SERP
    (on 24 Jan 2026 )
    Cellular Use Rating
    LC-04-45 is a potent CRBN-dependent NEK7 glue degrader, with established selectivity in MOLT-4 cells (human T lymphoblast cell line) at short time point (6h). LC-04-45-induced degradation of NEK7 has been...
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