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LC-04-45 | LC-04-45 : Molecular Glue of NEK7
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
NEK7
    • DC50:7 nM
    • IC50:33 nM
    • DC50:2.9 nM
    • IC50:33.03 nM
    • IC50:32.99
    Molecular Glue
    up to 1 uM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Proteome-wide selectivity was evaluated in MOLT-4 cells treated with 1 μM of LC-04-045 or DMSO for 6 ...
    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Selectivity against NEK1, NEK2, NEK4, NEK7, NEK10 and NEK11 was assessed via immunoblot in MOLLT4 ce ...

    Potency
    Cellular
    In Vitro

    NEK7

    Mode of Action: Molecular Glue

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1002/anie.202500169

    Negative Control Compounds

    LC-04-045-Neg
    Notes: LC-04-045-Neg was not able to promote the ternary complex formation in HEK293T cells.
    SMILES: O=C([C@@H](N(CC1=C2C=CC(C3=CN=C4CN(CC5=CC=CC=C5C6=CC=CC=C6Cl)CCN43)=C1)C2=O)CC7)N(C)C7=O

    Chemical Information

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    References

    Publications

    Cross References

    Expert Reviews

    by SERP
    (on 21 Jan 2026)
    Cellular Use Rating
    (The reviewer did not leave any public comments)
    by SERP
    (on 24 Jan 2026)
    Cellular Use Rating
    LC-04-45 is a potent CRBN-dependent NEK7 glue degrader, with established selectivity in MOLT-4 cells (human T lymphoblast cell line) at short time point (6h). LC-04-45-induced degradation of NEK7 has been...
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