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KS176 | KS176 : Inhibitor of ABCG2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ABCG2
    • IC50:590 nM
    • IC50:1.39±0.26 µM
    Inhibitor
    up to 10 µM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    Analysed for its potential interaction with MRP1 by using calcein AM assay and the multidrug-resista ...

    Potency
    Cellular
    In Vitro

    ABCG2

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1002/cmdc.201000216

    Orthogonal Probes def

    Ko-143

    Chemical Information

    Molecular Formula C22H19N3O5
    SMILEs O=C(Nc1ccccc1C(=O)Nc1ccc(CCO)cc1)c1ccc([N+](=O)[O-])cc1
    InChI InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27)
    Molecular weight 405.13 Da
    AlogP 3.6342000000000025
    HBond acceptors 8
    HBond donors 3
    Atoms 49

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    Expert Reviews

    No SERP comments found for KS176

    Probe KS176 is in the process of SERP review.

    Please continue to check back for new reviews and commentary.