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JP3000 | JP3000 : Agonist of RXRA, RXRB, RXRG
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
RXRA
  • IC50:<10 nM
  • EC50:5 ± 1 nM
  • EC50:2.6 ± 0.3 nM
  • EC50:29 ± 2 nM
  • EC50:~10 nM
RXRB
    • EC50:1.4 ± 0.4 nM
    RXRG
      • EC50:4 ± 1 nM
      Agonist
      between 100 nM and 1 uM

      Selectivity

      In Vitro Selectivity Assessment
      Potency Assay Off-Target:
      Tested on 27 related nuclear receptors at 1 µM (in-house panel): clean (> 100 fold selectivity)

      Potency
      Cellular
      In Vitro

      RXRA

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? Yes

      Other Reference: Peer reviewed at SGC

      RXRB

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? Yes

      Other Reference: Peer reviewed at SGC

      RXRG

      Mode of Action: Agonist

      Structure-Activity-Relationship data available? No

      Other Reference: Peer reviewed at SGC

      Negative Control Compounds

      JP3001
      Notes: EC50 (RXRα/β/γ): all > 10 µM (hybrid reporter gene assays)
      PubChem ID:

      Chemical Information

      Molecular Formula C21H13F6NO3
      SMILEs O=C(O)C1CC1c1nc(-c2ccccc2)c(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)o1
      InChI InChI=1S/C21H13F6NO3/c22-20(23,24)12-6-11(7-13(8-12)21(25,26)27)17-16(10-4-2-1-3-5-10)28-18(31-17)14-9-15(14)19(29)30/h1-8,14-15H,9H2,(H,29,30)
      Molecular weight 441.08 Da
      AlogP 0.0
      HBond acceptors 4
      HBond donors 1
      Atoms 44

      Vendors

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      Expert Reviews

      No SERP comments found for JP3000

      Probe JP3000 is in the process of SERP review.

      Please continue to check back for new reviews and commentary.