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JNJ-9350 | JNJ-9350 : Inhibitor of SMOX
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
SMOX
  • IC50:10 nM
  • Ki:9.9 nM
  • IC50:1200 nM
Inhibitor
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
PAOX IC50 = 790 nM (PAOX biochemical assay using HyPerBlu) (79-fold); KDM1A (LSD1): IC50 > 60 µM (Hy ...

Potency
Cellular
In Vitro

SMOX

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

Other Reference: Peer reviewed at SGC

In Vivo Validations

Mouse
Dose: 2 mg/Kg IV, 10 mg/Kg
Route of delivery: Intravenous, Oral
Plasma half life: 0.5 h
Fb : 98.6%
Bioavailability: 34%
Volume of Distribution at Steady-State: 1.7 L/Kg

Other Reference: Peer reviewed at SGC

Negative Control Compounds

CANSAR3894094
Notes: JNJ-4545: SMOX enzymatic assay: IC50 > 31 µM; PAOX IC50 = 2.1 µM (PAOX biochemical assay)

Chemical Information

Molecular Formula C25H22N6O
SMILEs O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1
InChI InChI=1S/C25H22N6O/c32-25(27-12-7-14-30-15-13-26-18-30)22-17-24-28-21(19-8-3-1-4-9-19)16-23(31(24)29-22)20-10-5-2-6-11-20/h1-6,8-11,13,15-18H,7,12,14H2,(H,27,32)
Molecular weight 422.19 Da
AlogP 0.0
HBond acceptors 7
HBond donors 1
Atoms 54

Expert Reviews

by SERP
(on 8 Jun 2023 )
Cellular Use Rating
In Model Organisms
10 µM is >10-fold higher than the enzymatic IC50 for the related counter-target PAOx. In addition, the off-target profiling suggests that other activities may be present at 10 µM. The user should consider...
by SERP
(on 31 Jul 2023 )
Cellular Use Rating
In Model Organisms
The compound offers a useful SMOX tool and as such contributes to the understanding of this target biology. The presence of an inactive and closely related analogue helps offset concerns around off-target...
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