Chemical Probes logo
JNJ-79883960 | JNJ-79883960 : Inhibitor of NLRP3
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NLRP3
    • IC50:27.6 nM
    Inhibitor
    up to 10 µM

    Selectivity

    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    Tested some of the other 11 human inflammasomes: A panel of inflammasome triggers was used to look a ...
    In Vitro Selectivity Assessment
    Selectivity Assessment Description:
    All analogs were clean in CEREP and DiscoverX kinase panel

    Potency
    Cellular
    In Vitro

    NLRP3

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1038/s44321-024-00181-4

    In Vivo Validations

    Mouse
    Dose: 1 mg/Kg IV, 5 mg/Kg PO
    Route of delivery: Intravenous, Oral
    Plasma half life: 0.96 IV, 1.56 PO h
    Systemic clearance: 6.21 mL/min/Kg
    Cmax: 314 nM PO
    Tmax: 0.5 h PO
    Bioavailability: 111%
    Volume of Distribution at Steady-State: 0.236 L/Kg

    DOI Reference: 10.1038/s44321-024-00181-4

    Negative Control Compounds

    canSAR7437562
    Notes: JNJ-78832000: NLRP3 PBMC IL1β: IC50 < 20 µM; NLRP3 PBMC IL6: IC50 > 20 µM; NLRP3 PBMC TNFα: IC50 > 20 µM

    Chemical Information

    Molecular Formula C18H15F3N8O2
    SMILEs CN(C)c1nn(CC(=O)Nc2ccc3nncn3n2)c(=O)c2ccc(C(F)(F)F)cc12
    InChI InChI=1S/C18H15F3N8O2/c1-27(2)16-12-7-10(18(19,20)21)3-4-11(12)17(31)28(26-16)8-15(30)23-13-5-6-14-24-22-9-29(14)25-13/h3-7,9H,8H2,1-2H3,(H,23,25,30)
    Molecular weight 432.13 Da
    AlogP 1.5576999999999996
    HBond acceptors 10
    HBond donors 1
    Atoms 46

    Expert Reviews

    by SERP
    (on 7 Dec 2025 )
    Cellular Use Rating
    In Model Organisms
    JNJ-79883960 is a potent and selective inhibitor of the NLRP3 inflammasome. It is active in cells, thus suitable as in vitro chemical probe. Target engagement has been shown for the series, e.g. by cryo-EM...
    by SERP
    (on 16 Dec 2025 )
    Cellular Use Rating
    In Model Organisms
    The primary paper of JNJ-79883960 reports the biophysical characterisation of members of the same chemical series by nano-DSF, biochemical assay (ATP hydrolysis inhibition), HDX and a cryo-EM structure....
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria