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JNJ-65355394 | JNJ-65355394 : Inhibitor of OGA
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OGA
  • IC50:1.3 nM
  • Ki:0.035 nM
  • IC50:3.9 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity within target family: > 30-fold HEXA IC50 > 10 µM. Selectivity outside target family: CE ...

Potency
Cellular
In Vitro

OGA

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

Other Reference: peer reviewed at SGC

In Vivo Validations

Mouse
Dose: 100 mg/Kg
Route of delivery: Oral

DOI Reference: 10.6019/CHEMBL4800731

Negative Control Compounds

CANSAR3597779
Notes: JNJ-73924149 Fluorescence-based enzymatic assay (IC50 > 10 µM); cell-based hOGA assay (IC50 > 1000 nM)

Chemical Information

Molecular Formula C19H26N4OS
SMILEs CC(=O)Nc1ncc(CN2CCC[C@H](Cc3cc(C)nc(C)c3)C2)s1
InChI InChI=1S/C19H26N4OS/c1-13-7-17(8-14(2)21-13)9-16-5-4-6-23(11-16)12-18-10-20-19(25-18)22-15(3)24/h7-8,10,16H,4-6,9,11-12H2,1-3H3,(H,20,22,24)/t16-/m1/s1
Molecular weight 358.18 Da
AlogP 0.0
HBond acceptors 5
HBond donors 1
Atoms 51

Expert Reviews

No SERP comments found for JNJ-65355394

Probe JNJ-65355394 is in the process of SERP review.

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