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JJKK-048 | JJKK-048 : Inhibitor of MGLL
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MGLL
  • IC50:0.363 nM
  • Inhibition:~60%
Inhibitor
10 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Activity assays using rat and human FAAH preparations revealed that JJKK-048 exhibited notable MAGL ...

Potency
Cellular
In Vitro

MGLL

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1016/j.chembiol.2013.01.012

In Vivo Validations

Mouse
Dose: 0.5-2 mg/Kg
Route of delivery: Intraperitoneal
Plasma half life: 0.5 h
Cmax: 0.003 uM (1.0 m/Kg), 0.175 uM (2.0 mg/Kg) plasma

DOI Reference: 10.1124/jpet.116.233114

Chemical Information

Molecular Formula C23H22N4O5
SMILEs O=C(N1CCC(C(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1)n1cncn1
InChI InChI=1S/C23H22N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12,15,22H,5-8,13-14H2
Molecular weight 434.16 Da
AlogP 0.0
HBond acceptors 9
HBond donors --
Atoms 54

Vendors

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Expert Reviews

No SERP comments found for JJKK-048

Probe JJKK-048 is in the process of SERP review.

Please continue to check back for new reviews and commentary.