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IPP/CNRS-A017 | Inhibitor of DHODH
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
DHODH
  • IC50:25 nM
  • EC50:2.5 nM
  • IC50:50 nM
Inhibitor
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity outside target family: GPCR screen (44 targets): Closest off-targets at 10 µM are GABA/ ...

Potency
Cellular
In Vitro

DHODH

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.5b00606

Negative Control Compounds

IPP/CNRS-A019

Chemical Information

Molecular Formula C21H20F3N3O2
SMILEs Cc1c(Oc2c(F)cccc2F)c(OC(C)C)nn1-c1ncc(C2CC2)cc1F
InChI InChI=1S/C21H20F3N3O2/c1-11(2)28-21-18(29-19-15(22)5-4-6-16(19)23)12(3)27(26-21)20-17(24)9-14(10-25-20)13-7-8-13/h4-6,9-11,13H,7-8H2,1-3H3
Molecular weight 403.15 Da
AlogP 5.449920000000003
HBond acceptors 5
HBond donors --
Atoms 49

Vendors

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Expert Reviews

by SERP+
(on 23 Sept 2024)
Cellular Use Rating
(The reviewer did not leave any public comments)
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria