IOX2 |
IOX2 : Inhibitor of EGLN1
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| EGLN1 |
|
|
Inhibitor
1 µM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
IOX2 was profiled against a panel of human histone Nε-methyl lysine demethylase 2OG-oxygenases in an ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
Selective inhibition of IOX2 in human cell lines. Selectivity of the tested inhibitors for HIF-1α pr ...
In Vitro Selectivity Assessment
Potency Assay Off-Target:
IOX2 was tested against a panel of other human 2OG oxygenases focusing on histone Nε-methyl lysine d ...
Potency Cellular
In Vitro
EGLN1
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? No
DOI Reference: 10.1007/s00204-015-1549-y
Chemical Information
| Molecular Formula | C19H16N2O5 |
| SMILEs | O=C(O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O |
| InChI | InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23) |
| Molecular weight | 352.11 Da |
| AlogP | 1.5698 |
| HBond acceptors | 7 |
| HBond donors | 3 |
| Atoms | 42 |