IMT1B |
IMT1B : Allosteric inhibitor of POLRMT
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| POLRMT |
|
|
Allosteric
up to 10 uM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
IMT1B did not inhibit budding yeast mitochondrial RNA polymerase (RPO41), bacteriophage T7 RNA polym ...
Potency Cellular
In Vitro
POLRMT
Mode of Action: Allosteric
Structure-Activity-Relationship data available? No
DOI Reference: 10.1038/s41586-020-03048-z
In Vivo Validations
Mouse
Dose: 1 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
1.88 h
Systemic clearance:
0.44 L/h/Kg
Area Under the Curve::
2256 h*ng/mL
Volume of Distribution at Steady-State:
1.2 L/Kg
DOI Reference: 10.1038/s41586-020-03048-z
Dose: 10 mg/Kg
Route of delivery:
Oral
Plasma half life:
2.72 h
Cmax:
5149 ng/mL
Tmax:
1.0 h
Area Under the Curve::
22854 h*ng/mL
Bioavailability:
101%
DOI Reference: 10.1038/s41586-020-03048-z
Negative Control Compounds
SC-6238532
Notes: SC-6238532 (con IMT) is structurally related to IMTs—and it neither binds POLRMT nor affects mtDNA expression.
SMILES:
CC1=C(OC(C(C(C)(C)C)=O)C)C=CC2=C1OC(C=C2C3=CC=CC=C3)=O
Chemical Information
| Molecular Formula | C24H21ClFNO6 |
| SMILEs | C[C@@H](Oc1ccc2c(-c3ccc(F)cc3Cl)cc(=O)oc2c1)C(=O)N1CCC[C@H](C(=O)O)C1 |
| InChI | InChI=1S/C24H21ClFNO6/c1-13(23(29)27-8-2-3-14(12-27)24(30)31)32-16-5-7-18-19(11-22(28)33-21(18)10-16)17-6-4-15(26)9-20(17)25/h4-7,9-11,13-14H,2-3,8,12H2,1H3,(H,30,31)/t13-,14+/m1/s1 |
| Molecular weight | 473.10 Da |
| AlogP | 4.343000000000003 |
| HBond acceptors | 7 |
| HBond donors | 1 |
| Atoms | 54 |