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IMR-687 | Inhibitor of PDE9A
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
PDE9A
  • IC50:9 nM
Inhibitor
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Radiometric assay
Selectivity Assessment Description:
MR-687 inhibited PDE9A with more than 800-fold greater potency than PDE1A3, PDE1B, PDE1C, PDE5A2, wi ...

Potency
Cellular
In Vitro

PDE9A

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.3324/haematol.2018.213462

Chemical Information

Molecular Formula C21H26N6O2
SMILEs C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1cn2c(C3CCOCC3)ncc2c(=O)[nH]1
InChI InChI=1S/C21H26N6O2/c1-14-10-26(13-19-22-5-2-6-23-19)11-16(14)17-12-27-18(21(28)25-17)9-24-20(27)15-3-7-29-8-4-15/h2,5-6,9,12,14-16H,3-4,7-8,10-11,13H2,1H3,(H,25,28)/t14-,16-/m1/s1
Molecular weight 394.21 Da
AlogP 1.9421
HBond acceptors 8
HBond donors 1
Atoms 55

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Expert Reviews

by SERP+
(on 22 Mar 2023 )
Cellular Use Rating
IMR-687 was tested against 33 PDEs and shows 800 fold selectivity against PDE9A1 and PDE9A2. However, specific in-cell data (e.g. target engagement) is missing to fully evaluate it as a cellular probe....
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