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IMP-1088 | Inhibitor of NMT1, NMT2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
NMT1
  • IC 50:< 1 nM
  • Kd:0.210 nM
  • IC 50:17 nM (C)
  • IC 50:5.8 nM
NMT2
      Inhibitor
      100 nM -1000 nM

      Selectivity

      Potency
      Cellular
      In Vitro

      NMT1

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1016/j.chembiol.2019.03.006

      NMT2

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1016/j.chembiol.2019.03.006

      Negative Control Compounds

      IMP-994

      Orthogonal Probes def

      IMP-366

      Chemical Information

      Molecular Formula C25H29F2N5O
      SMILEs Cc1nn(C)c(C)c1CCOc1c(-c2ccc3c(c2)c(CN(C)C)nn3C)ccc(F)c1F
      InChI InChI=1S/C25H29F2N5O/c1-15-18(16(2)31(5)28-15)11-12-33-25-19(8-9-21(26)24(25)27)17-7-10-23-20(13-17)22(14-30(3)4)29-32(23)6/h7-10,13H,11-12,14H2,1-6H3
      Molecular weight 453.23 Da
      AlogP 4.551940000000004
      HBond acceptors 6
      HBond donors --
      Atoms 62

      References

      Publications

      Cross References

      Vendors

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      Expert Reviews

      by SERP
      (on 18 Jun 2021 )
      Cellular Use Rating
      The cited reference (10.1016/j.chembiol.2019.03.006) is an excellent comparative study of the 5 cmpds that have been used as NMT probes and shows clearly and conclusively that only IMP-1088 and IMP-366...
      by SERP
      (on 30 Jun 2021 )
      Cellular Use Rating
      In Model Organisms
      ...
      by SERP
      (on 7 Jul 2021 )
      Cellular Use Rating
      There is no selectivity data indicating that this compound inhibits the intended target(s) without inhibiting other acyltransferases. Looking at the chemical structure, I would anticipate activity...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria