IBERDOMIDE |
IBERDOMIDE : Modulator of CRBN, Molecular glue IKZF1, IKZF3
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| CRBN |
|
|
| IKZF1 |
| |
| IKZF3 |
|
10-100 nM
Selectivity
In Cell Selectivity Assessment
Potency Assay Off-Target:
Treatment of B cells with Iberdomide (10 nM for 24 hours) resulted in a significant decrease in the ...
Potency Cellular
In Vitro
CRBN
Mode of Action: Modulator
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.6b01921
IKZF1
Mode of Action: Molecular Glues
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.6b01921
IKZF3
Mode of Action: Molecular Glues
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.6b01921
Chemical Information
| Molecular Formula | C25H27N3O5 |
| SMILEs | O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1 |
| InChI | InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1 |
| Molecular weight | 449.20 Da |
| AlogP | 0.0 |
| HBond acceptors | 8 |
| HBond donors | 1 |
| Atoms | 60 |