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HSL-IN-1 | HSL-IN-1 : Inhibitor of LIPE
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
LIPE
  • IC50:2 nM
    Inhibitor
    1 µM

    Selectivity

    Potency
    Cellular
    In Vitro

    LIPE

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1016/j.bmc.2017.02.045

    In Vivo Validations

    Rat
    Dose: 3 mg/Kg
    Route of delivery: Oral
    Cmax: 3.35 ug/mL
    Area Under the Curve:: 19.65 ug·h/mL

    DOI Reference: 10.1016/j.bmc.2017.02.045

    Negative Control Compounds

    CANSAR668256
    Notes: cpd 16a: IC50 920 nM HSL inhibition assay

    Chemical Information

    Molecular Formula C19H13BClF3N2O4
    SMILEs O=C(Nc1ccc(Cl)cc1B(O)O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1
    InChI InChI=1S/C19H13BClF3N2O4/c21-13-4-7-16(15(9-13)20(28)29)26-18(27)11-1-8-17(25-10-11)30-14-5-2-12(3-6-14)19(22,23)24/h1-10,28-29H,(H,26,27)
    Molecular weight 436.06 Da
    AlogP 3.478200000000002
    HBond acceptors 6
    HBond donors 3
    Atoms 43

    References

    Publications

    Cross References

    canSARChEMBLBindingDB

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    Expert Reviews

    by SERP
    (on 19 Oct 2022 )
    Cellular Use Rating
    In Model Organisms
    The probe would benefit from selectivity profiling, especially, off-target activity on other serine hydrolases, including DAG-lipase, MAG-lipase, ABHD6, carboxylesterase. Activity-based protein profiling...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria