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HS665 | HS665 : Agonist of OPRK1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OPRK1
  • Ki:0.49 ± 0.20 nM
  • EC50:3.62 ± 1.87 nM
Agonist
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
HS665 shows >1100-fold selectivity for KOP vs MOP receptors, and >20000-fold selectivity for KOP vs ...

Potency
Cellular
In Vitro

OPRK1

Mode of Action: Agonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm301258w

In Vivo Validations

Mouse
Dose: 2.5 mg/kg
Route of delivery: Subcutaneous

DOI Reference: 10.1021/jm301258w

Orthogonal Probes def

U-50488 METHANE SULFONATE

Chemical Information

Molecular Formula C21H27NO
SMILEs Oc1cccc(CCN(CCc2ccccc2)CC2CCC2)c1
InChI InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2
Molecular weight 309.21 Da
AlogP 4.279500000000004
HBond acceptors 2
HBond donors 1
Atoms 50

References

Publications

Cross References

Expert Reviews

by SERP
(on 22 Nov 2023 )
Cellular Use Rating
In Model Organisms
Data describing the selectivity profile of HS665 at MOP and DOP receptors has been provided, but an assessment of the selectivity against a broad panel of targets has not been shared. This would be particularly...
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