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HS665 | HS665 : Agonist of OPRK1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
OPRK1
  • Ki:0.49 ± 0.20 nM
  • EC50:3.62 ± 1.87 nM
Agonist
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
HS665 shows >1100-fold selectivity for KOP vs MOP receptors, and >20000-fold selectivity for KOP vs ...

Potency
Cellular
In Vitro

OPRK1

Mode of Action: Agonist

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/jm301258w

In Vivo Validations

Mouse
Dose: 2.5 mg/kg
Route of delivery: Subcutaneous

DOI Reference: 10.1021/jm301258w

Orthogonal Probes def

U-50488 METHANE SULFONATE

Chemical Information

Molecular Formula C21H27NO
SMILEs Oc1cccc(CCN(CCc2ccccc2)CC2CCC2)c1
InChI InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2
Molecular weight 309.21 Da
AlogP 4.279500000000004
HBond acceptors 2
HBond donors 1
Atoms 50

References

Publications

Cross References

Expert Reviews

by SERP
(on 22 Nov 2023)
Cellular Use Rating
In Model Organisms
Data describing the selectivity profile of HS665 at MOP and DOP receptors has been provided, but an assessment of the selectivity against a broad panel of targets has not been shared. This would be particularly...
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