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HPK1-IN-3 | HPK1-IN-3 : ATP-competitive of MAP4K1
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MAP4K1
  • IC50:0.25 nM
  • IC50:453 nM
  • EC50:108 nM
ATP competitive
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Selectivity within target family: Improved kinome selectivity for HPK1-IN-3 (>100× selectivity in ...

Potency
Cellular
In Vitro

MAP4K1

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acsmedchemlett.1c00096

In Vivo Validations

Mouse
Dose: 1 mg/Kg IV, 5 mg/Kg PO
Route of delivery: Intravenous, Oral
Systemic clearance: 30 mL/min/Kg
Bioavailability: 13%
Volume of Distribution at Steady-State: 61 L/Kg
Target engagement assay: Mean Residence Time 0.48h

DOI Reference: 10.1021/acsmedchemlett.1c00096

Rat
Dose: 1 mg/Kg IV, 5 mg/Kg PO
Route of delivery: Intravenous, Oral
Systemic clearance: 28 mL/min/Kg
Volume of Distribution at Steady-State: 2 L/Kg
Target engagement assay: Mean Residence Time 1.3 h

DOI Reference: 10.1021/acsmedchemlett.1c00096

Chemical Information

Molecular Formula C23H22F4N6O2
SMILEs COc1cc2c(cc1Nc1ncc(C(N)=O)c(Nc3c(F)cccc3C(F)(F)F)n1)CN(C)CC2
InChI InChI=1S/C23H22F4N6O2/c1-33-7-6-12-9-18(35-2)17(8-13(12)11-33)30-22-29-10-14(20(28)34)21(32-22)31-19-15(23(25,26)27)4-3-5-16(19)24/h3-5,8-10H,6-7,11H2,1-2H3,(H2,28,34)(H2,29,30,31,32)
Molecular weight 490.17 Da
AlogP 0.0
HBond acceptors 8
HBond donors 4
Atoms 57

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Vendors

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Expert Reviews

No SERP comments found for HPK1-IN-3

Probe HPK1-IN-3 is in the process of SERP review.

Please continue to check back for new reviews and commentary.