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HDAC2-In-11 | HDAC2-In-11 : Inhibitor of HDAC2
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
HDAC2
  • IC50:14 nM
  • Inhibition:Imax 71%
Inhibitor
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selectivity against HDAC1: Evaluation of H3K9 acetylation in HDAC2-KO K562 cells, showing an Imax of ...

Potency
Cellular
In Vitro

HDAC2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/acs.jmedchem.5c02022

In Vivo Validations

Rat
Dose: not revealed
Route of delivery: Intravenous
Bioavailability: Total brain-to-plasma ratio: 0.93
Organ of interest (O): brain

DOI Reference: 10.1021/acs.jmedchem.5c02022

Chemical Information

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Expert Reviews

No SERP comments found for HDAC2-In-11

Probe HDAC2-In-11 is in the process of SERP review.

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