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hCAII Degrader 11 | Degrader (PROTAC) of CA2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
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Chemical Information
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CA2
    • DC50:0.5 ± 0.3 nM
    • Dmax:100%
    Degrader (PROTAC)
    up to 100 nM, no 'hook effect' up to 15 uM

    Selectivity

    Potency
    Cellular
    In Vitro

    CA2

    Mode of Action: Degrader (PROTAC)

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1021/acs.jmedchem.2c01843

    Chemical Information

    Molecular Formula C32H41N5O7S
    SMILEs NS(=O)(=O)c1ccc(C(=O)NCCCCCCCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1
    InChI InChI=1S/C32H41N5O7S/c33-45(43,44)23-16-14-22(15-17-23)29(39)35-21-10-8-6-4-2-1-3-5-7-9-20-34-25-13-11-12-24-28(25)32(42)37(31(24)41)26-18-19-27(38)36-30(26)40/h11-17,26,34H,1-10,18-21H2,(H,35,39)(H2,33,43,44)(H,36,38,40)
    Molecular weight 639.27 Da
    AlogP 3.4781000000000004
    HBond acceptors 12
    HBond donors 5
    Atoms 86

    Expert Reviews

    by SERP
    (on 20 Feb 2025 )
    Cellular Use Rating
    This is a very potent hCAII degrader, but no biochemical or cellular selectivity has been measured. It cannot be excluded that other proteins are degraded so should be used with caution.
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria