Chemical Probes logo
GW869516X | GW869516X : Inhibitor of CSNK2A1, CSNK2A2
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
CSNK2A1
  • IC50:85.1 nM
  • Kd:78 nM
  • IC50:446 nM
CSNK2A2
  • IC50:33.7 nM
  • Kd:56 nM
  • IC50:319 nM
Inhibitor
up to 1 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
A previous study reported more than 70% inhibition of binding of 33 kinases in a broad KINOMEscan as ...

Potency
Cellular
In Vitro

CSNK2A1

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-023-01459-3

CSNK2A2

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1038/s41589-023-01459-3

Chemical Information

Molecular Formula C23H22N6O3
SMILEs COc1cc(Nc2ncc3c(C)nc(-c4cc5ccccc5[nH]4)n3n2)cc(OC)c1OC
InChI InChI=1S/C23H22N6O3/c1-13-18-12-24-23(26-15-10-19(30-2)21(32-4)20(11-15)31-3)28-29(18)22(25-13)17-9-14-7-5-6-8-16(14)27-17/h5-12,27H,1-4H3,(H,26,28)
Molecular weight 430.18 Da
AlogP 0.0
HBond acceptors 9
HBond donors 2
Atoms 54

References

Publications

Cross References

canSARChEMBLBindingDBPDB

Expert Reviews

by SERP
(on 2 Jan 2025 )
Cellular Use Rating
( The reviewer did not leave any comments )
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria