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GW1100 | GW1100 : Antagonist of FFAR1
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR1
    • IC50:1 uM
    Antagonist
    up to 10 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    GW1100 has no effect on the GPR120‐mediated stimulation of intracellular Ca2+ release; is shown to ...

    Potency
    Cellular
    In Vitro

    FFAR1

    Mode of Action: Antagonist

    Structure-Activity-Relationship data available? Yes

    DOI Reference: 10.1038/sj.bjp.0706770

    In Vivo Validations

    Mouse
    Dose: 10 ug/Mouse
    Route of delivery: Intracerebroventricular injection

    DOI Reference: 10.1038/sj.bjp.0706770

    Orthogonal Probes def

    FASIGLIFAM
    TUG-469
    AMG-837

    Chemical Information

    Molecular Formula C27H25FN4O4S
    SMILEs CCOC(=O)c1ccc(-n2cc(Cc3cnc(OCC)nc3)c(=O)nc2SCc2ccc(F)cc2)cc1
    InChI InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3
    Molecular weight 520.16 Da
    AlogP 4.6201
    HBond acceptors 8
    HBond donors --
    Atoms 62

    References

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    Vendors

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    Expert Reviews

    by SERP
    (on 1 Dec 2021 )
    Cellular Use Rating
    In Model Organisms
    GW1100 is a standard cellular and in vivo tool for antagonizing FFAR1/GPR120. It is commonly used to counteract the affects of GPR120 agonist GW9508 and long chain fatty acids. However, the in vivo mouse...
    Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria