GSK3484862 |
GSK3484862 : inhibitor of DNMT1
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| DNMT1 |
|
|
degrader/inhibitor
80 nM for incubation times >12h
up to 1 µM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
no inhibition of the family members DNMT3A/3L and DNMT3B/3L, or the assay coupling enzyme Gla1 when ...
Potency Cellular
In Vitro
DNMT1
Mode of Action: degrader/inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1093/narcan/zcad022
In Vivo Validations
Mouse
Dose: 2mg/Kg
Route of delivery:
Intravenous
Plasma half life:
1.8 h
Systemic clearance:
13 mL/min/kg
Cmax:
5103 ng/mL
Area Under the Curve::
2418 h*ng/mL (0-8h)
Volume of Distribution at Steady-State:
1.3 L/kg
DOI Reference: 10.1038/s43018-021-00249-x
Dose: 2 mg/Kg
Route of delivery:
Subcutaneous
Plasma half life:
2.8 h
Cmax:
252 ng/mL
Area Under the Curve::
921 h*ng/mL (0-8 h)
DOI Reference: 10.1038/s43018-021-00249-x
Dose: 30 mg/Kg
Route of delivery:
Subcutaneous
Cmax:
5473 ng/mL
Area Under the Curve::
15400 h*ng/mL (0-8 h)
DOI Reference: 10.1038/s43018-021-00249-x
Chemical Information
| Molecular Formula | C19H19N5OS |
| SMILEs | CCc1c(C#N)c(SC(C(N)=O)c2ccccc2)nc(N(C)C)c1C#N |
| InChI | InChI=1S/C19H19N5OS/c1-4-13-14(10-20)18(24(2)3)23-19(15(13)11-21)26-16(17(22)25)12-8-6-5-7-9-12/h5-9,16H,4H2,1-3H3,(H2,22,25) |
| Molecular weight | 365.13 Da |
| AlogP | 0.0 |
| HBond acceptors | 6 |
| HBond donors | 2 |
| Atoms | 45 |