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GPR120-IN-1 | Agonist of FFAR4
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (3 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
FFAR4
    • pEC50:7.6
    Agonist
    up to 10 uM

    Selectivity

    In Cell Selectivity Assessment
    Selectivity Assessment Description:
    No activity detected on FFAR1 in both human and mouse variants.

    Potency
    Cellular
    In Vitro

    FFAR4

    Mode of Action: Agonist

    Structure-Activity-Relationship data available? No

    In Vivo Validations

    Mouse
    Dose: 30 mg/Kg

    Reference: --

    Orthogonal Probes def

    TUG-891

    Chemical Information

    Molecular Formula C19H23ClF3NO3
    SMILEs O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2
    InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
    Molecular weight 405.13 Da
    AlogP 5.490100000000004
    HBond acceptors 4
    HBond donors 1
    Atoms 50

    References

    Publications

      Cross References

      Vendors

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      Expert Reviews

      by SERP
      (on 26 Jul 2021 )
      Cellular Use Rating
      In Model Organisms
      This probe (cpdA) was demonstrated to show excellent cellular activity on and submicromolar activity in a cellular beta-arrestin interaction assay in GPR120-transfected cells. In vivo, the probe was...
      by SERP
      (on 5 Aug 2021 )
      Cellular Use Rating
      In Model Organisms
      There is insufficient off-target data on the compound and no raw data were supplied to assess the efficacy and potency of the compound of interest. Without a negative control as well as comprehensive...
      by SERP
      (on 6 Oct 2021 )
      Cellular Use Rating
      In Model Organisms
      Up to 500 micromoles/L of GPR120-IN-1 can be applied topically to the mouse tongue to stimulate fatty acid taste reception; Yasumatsu et al. (doi:10.111/apha.13215) have established, using GPR120 knockout...
      Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria