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Golvatinib | Inhibitor of MET, KDR
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MET
    • IC50:14 nM
    • IC50:24 nM
    • IC 50:23 nM
    KDR
      • IC50:16 nM
      • IC 50:6.2 nM
      • IC50:37 nM
      Inhibitor
      up to 5 uM

      Selectivity

      Potency
      Cellular
      In Vitro

      MET

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1111/j.1349-7006.2009.01343.x

      KDR

      Mode of Action: Inhibitor

      Structure-Activity-Relationship data available? No

      DOI Reference: 10.1111/j.1349-7006.2009.01343.x

      In Vivo Validations

      Mouse
      Dose: 50-200 mg/Kg
      Route of delivery: Oral

      DOI Reference: 10.1111/j.1349-7006.2009.01343.x

      Orthogonal Probes def

      abozantinib

      Chemical Information

      Molecular Formula C33H37F2N7O4
      SMILEs CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1
      InChI InChI=1S/C33H37F2N7O4/c1-40-16-18-41(19-17-40)24-9-14-42(15-10-24)32(45)39-29-21-26(8-13-36-29)46-25-6-7-28(27(35)20-25)38-31(44)33(11-12-33)30(43)37-23-4-2-22(34)3-5-23/h2-8,13,20-21,24H,9-12,14-19H2,1H3,(H,37,43)(H,38,44)(H,36,39,45)
      Molecular weight 633.29 Da
      AlogP 4.7532
      HBond acceptors 11
      HBond donors 3
      Atoms 83

      Vendors

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      Expert Reviews

      No SERP comments found for Golvatinib

      Probe Golvatinib is in the process of SERP review.

      Please continue to check back for new reviews and commentary.